QUININE DIHYDROCHLORIDE INJECTION 600mg 2ml

QUININE DIHYDROCHLORIDE INJECTION 600mg 2ml

  • Documents: GMP,COPP,CTD

QUININE DIHYDROCHLORIDE INJECTION 600mg 2ml

Indications:

Quinine Dihydrochloride injection is indicated for the acute treatment of malaria. It may also be used in the treatment of Babesiosis in conjunction with clindamycin.

Dosage and Administration:

Child and adult:

Loading dose: 20 mg/kg administered over 4 hours, then keep the vein open with an infusion of 5% glucose over 4 hours

Maintenance dose: 8 hours after the start of the loading dose, 10 mg/kg every 8 hours (alternate quinine over 4 hours and 5% glucose over 4 hours)

For adults, administer each dose of quinine in 250 ml. For children under 20 kg, administer each dose of quinine in a volume of 10 ml/kg.

Do not administer a loading dose to patients who have received oral quinine or mefloquine within the previous 24 hours: start with maintenance dose.

Duration

Treat parenterally for at least 24 hours, then, if the patient can tolerate the oral route, change to a complete 3-day course of an artemisinin-based combination (or if not available oral quinine to complete 7 days of quinine treatment). If not, continue parenteral treatment until the patient can change to oral route (without exceeding 7 days of parenteral treatment).

Precautions & Warning:

Check for hypersensitivity to quinine or quinidine BEFORE administration. It is important that when given intravenously it should be given by SLOW infusion and the patient observed closely for signs of cardiotoxicity.

The half-life of quinine is prolonged in hepatitis and moderate chronic liver disease.

These symptoms should also be monitored during treatment:

Haemolysis

Prothrombin formation

Atrial fibrillation

Hypersensitivity

Contra-indications:

• Hypersensitivity to quinine or quinidine

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency

• History of Blackwater Fever

• Patients with tinnitus or optic neuritis

• It should not be used in the presence of haemolysis or in the presence of concurrent anticoagulant therapy

• It should not be used in patients with diabetes

Drug interactions:

Urinary alkalinisers

Urinary acidifiers

Cimetidine

Digoxin

Anticoagulants:

Pyrimethamine

Neuromuscular blocking agents

Antiarrhythmics

Anticholinesterases

Diuretics

Antineoplastics

Antibacterials

Ganglion blockers:

General anaesthetics

Magnesium salts

Sympathomimetics (Salbutamol)

Other: Antimyasthenics, haemolytics, neurotoxic medication, ototoxic medication, mefloquine, lithium and quinidine.

Storage instructions:

Store below 25°C and protect from light