Indications

1. Administration of glucose for caloric support

2. Carbohydrate component in parenteral nutrition regimens

3. Therapy of hypoglycaemia

Dosage and Administration

Dosage:

The infusion rate and volume of Glucose Injection is dependent upon the age, weight, concomitant therapy, clinical and metabolic conditions of the patient as well as laboratory determinations. Electrolyte supplementation may be indicated according to the clinical need soft he patient. As indicated on an individual basis, vitamins and trace elements and other components (including amino acids and lipids) can be added to the parenteral regimen to meet nutrient needs and prevent deficiencies and complications from developing.

Usage: To be used for intravenous administration as directed by the physician.

Precautions & Warning:

1.General

Glucose Intravenous Injection 30% w/v is a hypertonic solution. In the body, however, glucose containing fluids can become extremely physiologically hypotonic due to rapid glucose metabolization .

Depending on the tonicity of the solution, the volume and rate of infusion and depending on a patient's underlying clinical condition and capability to metabolize glucose, intravenous administration of glucose can cause electrolyte disturbances most importantly hypo- or hyperosmotic hyponatraemia.

2.Hypersensitivity reactions

Hypersensitivity/infusion reactions, including anaphylactic/anaphylactoid reactions, have been reported with glucose infusions. The infusion must be stopped immediately if any signs or symptoms of a suspected hypersensitivity reaction develop. Appropriate therapeutic countermeasures must be instituted as clinically indicated.

3.Dilution and other effects on serum electrolytes 

The administration of glucose infusions can cause fluid and/or solute overloading resulting in dilution of the serum electrolyte concentrations, over‐hydration, congested states, or pulmonary oedema. The risk of dilution states is inversely proportional to the electrolyte concentrations of the injections. The risk of solute overload causing congested states with peripheral and pulmonary oedema is directly proportional to the electrolyte concentrations of the injections.  Excessive administration of high concentration glucose infusions may result in significant hypokalaemia, requiring possible administration of concomitant potassium. 

4.Hyperglycaemia 

As with the intravenous administration of nutrients (e.g., glucose, amino acids and lipids) in general, metabolic complications may occur if the nutrient intake is not adapted to the patient’s requirements, or the metabolic capacity of any given dietary component is not accurately assessed. Adverse metabolic effects may arise from administration of inadequate or excessive nutrients or from inappropriate composition of an admixture for a particular patient’s needs. 

Contraindications:

1.Hyperglycaemia, not responding to insulin doses of up to 6 units insulin/hour

2.Delirium tremens if such patients are already dehydrated

3.Acute states of shock and collapse

4.Metabolic acidosis

5.Since the administration of glucose solutions is accompanied by the administration of free water, further contraindications may arise e.g.: Hyperhydration; Pulmonary oedema; Acute congestive heart failure

Adverse Reactions:

Undesirable effects are listed according to their frequencies as follows:

General disorders and administration site conditions:

Not known: Local reactions at the site of administration, including local pain, vein irritation, thrombophlebitis or tissue necrosis in case of extravasation.

Metabolism and nutrition disorders:

Not known: Hospital Acquired Hyponatraemia

Nervous system disorders:

Not known: Hyponatraemic encephalopathy

Storage instructions:

This medicinal product does not require any special storage conditions.

For storage conditions after dilution of the medicinal product