Indications

1.Amoxicillin Powder for Oral Suspension Sugar Free is indicated for the treatment of the following infections in adults and children  such as:Acute bacterial sinusitis; Acute otitis media; Acute streptococcal tonsillitis and pharyngitis; Acute exacerbations of chronic bronchitis; Community acquired pneumonia; Acute cystitis; Asymptomatic bacteriuria in pregnancy; Acute pyelonephritis; Typhoid and paratyphoid fever; Dental abscess with spreading cellulitis; Prosthetic joint infections; Helicobacter pylori eradication; Lyme disease

2.Amoxicillin Powder for Oral Suspension Sugar Free is also indicated for the prophylaxis of endocarditis.

Dosage and Administration

Usage: oral

1.Adults and childrens with a mass more than 40kg: 250mg to 500mg three times per day. The latter dosage is for the more severe infections.

Fir in between ages, in between percentages are used, e.g at 10 years 66% and at three years 33% of the adult dose. The above percentage methods of calculating dosage is based on the formula.

Surface are of child * 100 = percentage of adult dose

Surface area of adult

2.Infants: The recommended dosage is 20 mg/kg/day in three equally divided doses. Direction of Mixing: Add freshly boiled, cooled water up to the mark on the bottle and shake vigorously. Adjust the volume up to the mark buy adding more water if necessary. This makes a 100ml suspension. The prepared suspension should be used one week after preparation and should be stored in a cool place. Protect from light.

Precautions & Warning:

1.Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are most likely in those with a history of hypersensitivity to betalactam antibiotics.

2.Amoxicillin should be used with caution in those with impaired renal function and dose reduction may be necessary in severe impairment.

3.Patients with infectious mononucleosis (glandular fever), lymphatic leukaemia and possibly with HIV infection are particularly prone to developing erythematous rashes with amoxicillin. Amoxicillin should be discontinued if a skin rash occurs.

4.Prolonged use of an anti-infective may result in the overgrowth of non-susceptible organisms (superinfection).

Contraindications:

1.Amoxicillin is contra-indicated in patients with hypersensitivity to penicillins. 2.Attention should also be paid to possible cross-reactivity with other beta-lactam antibiotics e.g. cephalosporins.

3. It should not be given to patients with infectious mononucleosis (glandular fever) since they are especially susceptible to amoxicillin-induced skin rashes.

Adverse Reactions:

1.When Amoxicillin is administered to a hypersensitive patient anaphylactic shock with collapse and sometimes death may occur within minutes.

2.Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and bullous and exfoliative dermatitis have been reported.

3.Severe allergic reactions including angioneurotic oedema, anaphylaxis, serum sickness and vasculitis reported rarely.

4.Nausea, vomiting diarrhoea. Muco-cutaneous candidiasis. Antibiotic-associated colitis, raised liver enzymes (AST and/or ALT), dizziness, convulsions and paraesthesia.

Storage instructions:

Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children. Use the reconstituted oral suspension within 7 days of preparation.