5% GLUCOSE AND 0.45% SODIUM CHLORIDE INJECTION
Indications
Treatment of dehydration or hypovolaemia in cases where supply of water, sodium chloride and carbohydrates is required due to restriction of the intake of fluids and electrolytes by normal routes.
Dosage and Administration
Usage:I.V.
The choice of the specific sodium chloride and glucose concentration, dosage, volume, rate and duration of administration depends on the age, weight, clinical condition of the patient and concomitant therapy. It should be determined by a physician.
Precautions & Warning:
1.Hyponatraemia:
The infusion of solutions with sodium concentrations <0.9% may result in hyponatraemia. Close clinical monitoring may be warranted.
2.Sodium retention, fluid overload and oedema
3.Hypokalaemia
4.Hypo- and hyperosmolality, serum electrolytes and water imbalance
5.Hyperglycaemia
Contraindications:
1. Known hypersensitivity to the product
2. Extracellular hyperhydration or hypervolaemia
3. Fluid and sodium retention
4. Severe renal insufficiency (with oliguria/anuria)
5. Uncompensated cardiac failure
6. Hyponatraemia or hypochloraemia
7. General oedema and ascitic cirrhosis
Adverse Reactions:
Frequencies cannot be estimated from the available data as all listed adverse reactions are based on spontaneous reporting
Drug interactions:
1.Both the glycaemic and effects on water and electrolyte balance should be taken into account when administering Sodium Chloride 0.45 % w/v and Glucose 5.0 % w/v solution to patients treated with other substances that affect glycaemic control or fluid and/or electrolyte balance.
2.Drugs leading to an increased vasopressin effect
The below listed drugs increase the vasopressin effect, leading to reduced renal electrolyte free water excretion and increase the risk of hospital acquired hyponatraemia following inappropriately balanced treatment with i.v. fluids.
1) Drugs stimulating vasopressin release, e.g.: Chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4-methylenedioxy-N-methamphetamine, ifosfamide, antipsychotics, narcotics
2) Drugs potentiating vasopressin action, e.g.: Chlorpropamide, NSAIDs, cyclophosphamide
3) Vasopressin analogues, e.g.: Desmopressin, oxytocin, terlipressin
4) Other medicinal products increasing the risk of hyponatraemia also include diuretics in general and antiepileptics such as oxcarbazepine.
Storage instructions:
No special precautions for storage.