Indications1.Urinary tract infections2.Bacterial gastrointestinal infections3.Osteomyelitis4.Infection of the respiratory tractDosage and AdministrationUsage:1.The adult oral dose of Ciprofloxacin ran
Indications
1.Urinary tract infections
2.Bacterial gastrointestinal infections
3.Osteomyelitis
4.Infection of the respiratory tract
Dosage and Administration
Usage:
1.The adult oral dose of Ciprofloxacin ranges from 500 to 750 mg twice daily depending on the severity and nature of the infection. A single oral dose of 500 mg is suggested for the treatment of gonorrhoea (by WHO) and also for meningococcal meningitis prophylaxis.
2.Ciprofloxacin is not generally recommended in children and adolescents but if considered essential, doses of 7.5 to 15 mg per kg of body-weight daily by mouth have been suggested.
Precautions & Warning:
1.Ciprofloxacin should be used with caution in patients with epilepsy or a history of CNS disorders. Since Ciprofloxacin have been shown to cause degenerative changes in weight- bearing joints of young animals, it has been suggested that these compounds should not be used in children adolescents, pregnant women, or breastfeeding mothers.
2.Care is necessary in patients with impaired hepatic or renal function, glucose- 6- phosphate dehydrogenase deficiency, or myasthenia gravis.
3.An adequate fluid intake should be maintained during treatment with Ciprofloxacin and excessive alkalinity of the urine avoided because of the risk of crystalluria. 4.Exposure to strong sunlight or sunlamps should also be avoided. The ability to drive or operate machinery may be impaired by Ciprofloxacin, especially when alcohol is also taken.
5.Ciprofloxacin may interact with various compounds including antacids, iron preparations, opioids, theophylline, and warfarin.
Contraindications:
Ciprofloxacin should not be given with known hypersensitivity to Ciprofloxacin or other quinolone antibiotics.
Adverse Reactions:
A series of 15 cases of anaphylactoid reactions has been reported associated with ciprofloxacin Stevens-Johnson syndrome, toxic epidermal necrolysis, fluminant hepatic failure and acute renal failure have been reported rarely.
Severe of irreversible adverse effects
As with all quinolones seizures may occur and this effects may be potentiated by concurrent use of non-steroidal anti-inflammatory drugs. Pseudomembranous colitis has occurred with ciprofloxacin therapy. Transient disturbance of hearing has been reported, particularly during high- dose therapy.
Symptomatic adverse effects
Probable or possible drug- related related reaction were reported in 9.3% of 9473 patients treated with ciprofloxacin worldwide. The incidence of severe reaction was 0.6% . The most frequent reaction were from the gastrointestinal system (nausea, diarrhea, vomiting, dyspepsia), central nervous system (dizziness, headache, nervousness, tremors, seizures, confusion) and skin (rash, pruritus, urticaria, photo sensitivity).
Other effects
Elevation of AST (SGOT) and ALT (SGPT), blood creatinine and blood urea have been observed. Eosinophilia, leucopenia and thrombocytopenia have also been related to ciprofloxacin use.
Drug interactions:
Antacids and other cations; Theophylline; Anticoagulants;
Storage instructions:
Store in a cool, dry and dark place. Protect from light.